He is meeting on Friday with Turkey's foreign minister after talks with President Recep Tayyip Erdogan to try to bring Turkey into a consensus to prevent Syria from collapsing into wider turmoil. It's Blinken's 12th trip to the Mideast since the Israel-Hamas war erupted in Gaza last year but first since the ouster of Syrian President Bashar Assad.
The outgoing Biden administration is particularly concerned that a power vacuum in Syria could exacerbate already heightened tensions in the region and create conditions for the Islamic State group to regain territory and influence.
The fighting between Israel and Hamas has plunged Gaza into a severe humanitarian crisis. Israel's offensive has killed over 44,800 Palestinians in Gaza, more than half of them women and children, according to the Gaza Health Ministry, which does not say how many were combatants. The Israeli military claims it has killed over 17,000 militants.
The war in Gaza was sparked by an Oct. 7, 2023, attack by Hamas in southern Israel in which some 1,200 people, mostly civilians, were massacred and around 250 others were taken hostage. Some 100 hostages are still inside Gaza, at least a third of whom are believed to be dead.